Synonyms : 4-Cyano-4-(3-(cyclopentyloxy)-4-(methoxy-d₃)phenyl)cyclohexane-1-carboxylic acid; SB-207499-d₃

Applications : Cilomilast-d3 is a deuterium labelled version analog of Cilomilast. A potent, selective and orally active inhibitor of Phosphodiesterase 4 (PDE4), with IC50s of ~100 and 120 nM for LPDE4 and HPDE4, respectively. Cilomilast shows selectivity for PDE4 over PDE1, PDE2, PDE3 and PDE5 (IC50=74, 65, >100, and 83 µM, respectively). Cilomilast has anti-inflammatory and immunomodulatory effects and can be used for thr research of asthma and chronic obstructive pulmonary disease (COPD).

References : Griswold D. E. et al.: J. Pharmacol Exp Ther., 287(2), 705-711, 1998; Hatzelmann A. et al.: J. Pharmacol Exp Ther., 297(1), 267-279, 2001; Barnette M. S. et al.: J. Pharmacol Exp Ther., 284(1), 420-426, 1998.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.