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SI-5179

RPL-554, >98% (HPLC)

CAS No. : 
[298680-25-8]    
Synonyms : (E)-1-(2-(2-(Mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl)ethyl)urea; LS-193855

Price and Availability
Pack Size Price in USD Quantity Availability Shipping Status
5MGRequest QuoteBack Order Estimated to Ship on 01.20.2025
25MGRequest QuoteBack Order Estimated to Ship on 01.20.2025
100MGRequest QuoteBack Order Estimated to Ship on 01.20.2025
250MGRequest QuoteBack Order Estimated to Ship on 01.20.2025
500MGRequest QuoteBack Order Estimated to Ship on 01.20.2025

RPL-554 is not in stock, can be available through custom synthesis. The estimated lead-time is 4-6 weeks. The product will be characterized by NMR and MS analysis. Purity (HPLC) is usually >98%. COA, QC data, SDS will be provided along with the product. For information on pricing and availability please contact us at sales@syninnova.com or submit the following Bulk Quote Request. We respond promptly. Thank You!

Chemical Properties
C26H31N5O4 477.57
Solid Not available
For Laboratory research use only, not for drug, household or other uses.
Applications : RPL-554 is a potent and selective PDE3/4 inhibitor. RPL-554 acts as a long-acting inhibitor of the phosphodiesterase enzymes PDE-3 and PDE-4, producing both bronchodilator and antiinflammatory effects. RPL-554 is a potential treatment for asthma and hay fever, and is currently in clinical trials.
References : Calzetta L. et al.: Pulm Pharmacol Ther., 32, 15-23, 2015; Franciosi L. G. et al.: Lancet Respir Med., 1(9), 714-27, 2013; Wedzicha J. A. et al.: Lancet Respir Med.1(9):669-70, 2013; Calzetta L. et al.: J. Pharmacol Exp Ther., 346(3), 414-23, 2013; Boswell-Smith V. et al.: J. Pharmacol Exp Ther., 318(2), 840-8, 2006.
Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.
Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Product ID : SI-5179

Product Name : RPL-554

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