[1346546-69-7]    

MFCD30481302

Synonyms : N-(6-(Isopropylsulfonyl)quinolin-4-yl)benzo[d]thiazol-5-amine

Applications : GSK-872 is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM. GSK-872 decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury.

References : Mandal P. et al.: Mol Cell., 56(4), 481-495, 2014; Arora D. et al.: Biochem Biophys Res Commun., 479(2), 217-223, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.