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SI-5210

GSK-872 hydrochloride, >98% (HPLC)

CAS No. : 
[2703752-81-0]    
Synonyms : N-(6-(Isopropylsulfonyl)quinolin-4-yl)benzo[d]thiazol-5-amine hydrochloride

Price and Availability
Pack Size Price in USD Quantity Availability Shipping Status
10MG130.00 Back Order Estimated to Ship on 01.20.2025
25MG250.00 Back Order Estimated to Ship on 01.20.2025
50MG450.00 Back Order Estimated to Ship on 01.20.2025
100MG750.00 Back Order Estimated to Ship on 01.20.2025
250MG1450.00 Back Order Estimated to Ship on 01.20.2025
Chemical Properties
C19H17N3O2S2 . HCl 419.94
Solid Not available
For Laboratory research use only, not for drug, household or other uses.
Applications : GSK-872 hydrochloride is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM. GSK-872 hydrochloride decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury.
References : Mandal P. et al.: Mol Cell., 56(4), 481-495, 2014; Arora D. et al.: Biochem Biophys Res Commun., 479(2), 217-223, 2016.
Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.
Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Product ID : SI-5210

Product Name : GSK-872 hydrochloride

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