[1956366-10-1]    

MFCD22543853

Synonyms : (S)-4-(5-Chloro-2-(isopropylamino)pyridin-4-yl)-N-(1-(3-chlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamide hydrochloride; BVD-523 hydrochloride; VRT752271 hydrochloride

Applications : Ulixertinib hydrochloride is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC50 of <0.3 nM against ERK2. Ulixertinib hydrochloride inhibits the phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) in an A375 melanoma cell line.

References : Ward R. A. et al.: J Med Chem., 58(11), 4790-801, 2015; Kumar R. et al.: J. Pharm Biomed Anal., 125, 140-4, 2016; Ning C. et al.: Oncotarget., 8(27), 44295-44311, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.