[792173-99-0]    

MFCD06411602

Synonyms : 1-(2-Methylbenzo[d]oxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea

Applications : SB-334867 is an excellent, selective and blood–brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 (pKb=7.4), 100-fold over 5-HT2B, 5-HT2C with pKi values of 5.4 and 5.3, respectively. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo.

References : Porter R. A. et al.: Bioorg Med Chem Lett., 11(14), 1907-10, 2001; Anderson R. I. et al.: Front Neurosci., 8, 33, 2014; Smart D. et al.: Br. J. Pharmacol., 132(6), 1179-82, 2001.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.