SynInnova Laboratories Inc.

SL-1186

Bosutinib, 98%

CAS No. :

[380843-75-4]

MDL No. :

MFCD07367846

Synonyms : 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile

Price and Availability
Pack Size	Price in USD	Quantity	Availability	Shipping Status
25MG	125.00	- +	Back Order	Estimated to Ship on 12.14.2024
250MG	1080.00	- +	Back Order	Estimated to Ship on 12.14.2024

Chemical Properties
Mol. Formula : C₂₆H₂₉C_l2N₅O₃	Mol. Weight : 530.45
Appearance : White solid	Melting Point : 144-147^oC (lit.)
For Laboratory research use only, not for drug, household or other uses.

Applications : It is a novel dual inhibitor of Abl and Src kinases (IC₅₀ = 1.2 nM for Src in an enzymatic assay). Displays antiproliferative activity against chronic myelogenous leukemia (CML) cells and decreases the motility and invasion of breast cancer cell lines. Also exhibits potent antiproliferative activity in anchorage-independent, Src-transformed rat fibroblasts (IC50 = 100 nM). Displays selectivity for Src over non-Src family kinases such as growth factor receptor tyrosine kinases.

References : Boschelli. D. H. et. al.: J. Med. Chem. 44(23), 3965-3977, 2001; PMID: 11689083.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Product ID : SL-1186

Product Name : Bosutinib

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SL-1186

Bosutinib, 98%

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