[289711-21-3] of the unlabelled compound

Synonyms : L-γ-Glutamyl-S-[[[4-(methylsulfinyl)butyl-d₈]amino] -thioxomethyl]-L-cysteinylglycine; L-Glutamyl-S-[[[4-(methylsulfinyl)butyl-d₈]amino]thioxomethyl]-L-cysteinyl-glycine; SFN-GSH-d₈

Applications : It is a deuterium labelled conjugate of Sulforaphane (butyl-d8) and Glutathione. In vivo, sulforaphane conjugates with glutathione during metabolism. In animal models of prostate cancer, this conjugate displays antioxidative and anticancer chemotherapeutic activities, increasing levels of heme oxygenase 1 (HO-1), Nrf2, activated caspase 3, cleaved PARP, and Bax, decreasing levels of Keap1, Bcl-xl, 4E-BP1, mTOR, and cyclin D1, and slowing tumor growth.

References : Keum Y.S .et al.: Pharm Res. Oct, 26 (10), 2324-2331, 2009; PMID: 19669099.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.