[261766-32-9]    

MFCD02683391

Synonyms : 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-N-(2-phenylethyl)-1H-indole-3-acetamide; N-2PIA

Applications : N-(2-Phenylethyl)-indomethacin amide (N-2PIA) is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2. N-2PIA inhibits human recombinant and ovine COX-2 with IC₅₀ values of 0.06 and 0.125 µM, respectively. It is over 400 times less potent as an inhibitor of human recombinant and ovine COX-1. N-2PIA shows anti-inflammatory, antiangiogenic, and cancer chemopreventive activity in various experimental models.

References : Kalgutkar. A. S. et al.; J. Med.Chem., 43, 2860-2870, 2000

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.