Synonyms : 1-[2-[(2,4-Dimethylphenyl)thio]phenyl]-piperazine-d₈ hydrobromide; Lu AA 21004-d₈ hydrobromide

Applications : It is a deuterium labelled analog of Vortioxetine. A inhibitor of 5-HT_1A, 5-HT_1B, 5-HT_3A, 5-HT7 receptor and SERT, with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.

References : Bang-Andersen B et al.: J. Med. Chem., 54 (9), 3206-3221, 2011; Guilloux J. P. et al.: Neuropharmacology 73C, 147-159, 2013; Theunissen E. L et al.: Clin Pharmacol Ther., 93 (6), 493-501, 2013; Rothschild A. J. Eur Neuropsychopharmacol., 22 (12), 858-66, 2012; Mark A et al.: J. Pharmacol Exp Ther., 340 (3), 666-75, 2012; Vieta. E. et al.: Eur Neuropsychopharm, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.