[55-18-5]    

MFCD00013890

Synonyms : Diethylnitrosamine

Applications : N-Nitrosodiethylamine (DEN) is a widely occurring nitrosamine that is one of the most important environmental carcinogens (1) primarily inducing tumors of liver (2,3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. NDMA and NDEA were found as an impurity in generic versions of valsartan, losartan and irbesartan.

References : Oda Y. et al.: Mutation Research, Genetic Toxicology and Environmental Mutagenesis, 584, 1, 2005; Yamazaki H. et al.: Carcinogenesis, 13, 1789, 1992; Chem. and Eng. News, p.5, Feb. 25, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.