[85-18-7]    

MFCD00005581

Synonyms : 8-Chloro-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione

Applications : It is an advanced key intermediate in the preparation of Theophylline related analogs, which is a nonselective phosphodiesterase (PDE) inhibitor, adenosine receptor blocker, and histone deacetylase (HDAC) activator; used in therapy for respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma.

References : Deree J. et al. Clinics (Sao Paulo) 63(3), 321-328, 2008; Marques L. J. et al.: Am J. Respir Crit Care Med., 159(2), 508-511, 1999; Daly J. W.: et al. Prog Clin Biol Res., 230, 41-63, 1987.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.