[476305-24-5]    

Synonyms : Simvastatin USP related compound D; Simvastatin dimer

Applications : It is an impurity of Simvastatin (Simvastatin EP impurity D), which is a competitive inhibitor of HMG-CoA reductase. It is a lipid-lowering medication. It is used along with exercise, diet, and weight loss to decrease elevated lipid levels. It is also used to decrease the risk of heart problems in those at high risk.

References : Slater E. E. et al.: Drugs. 36 Suppl 3, 72-82, 1988; Kureishi Y. et al.: Nat Med, 6(9), 1004-1010, 2000; Leung B. P. et al. J Immunol, 170(3), 1524-1530, 2003; Kobayashi M. et al.: J. Pharmacol, 49(1), 125-133, 1989; Ishida F. et al.: Biochim Biophys Acta, 1042(3), 365-373, 1990; Sukhova G. K. et al. Arterioscler Thromb Vasc Biol, 22(9), 1452-1458, 2002; Dansette P. M. et al.: Exp. Toxicol Pathol, 52(2), 145-148, 2000.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.