[1356847-97-6]    

Synonyms : (2S)-1-[(2S)-6-Amino-2-[[(2S)-1-[[[(5S)-5-[[(1S)-1-carboxy-3-(phenyl-d₅)propyl]amino]-6-[(2S)-2-carboxypyrrolidin-1-yl]-6-oxohexyl]amino]carbonyl]-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid; Lisinopril-d₅ dimer

Applications : This is a deuterium labelled version impurity of Lisinopril (Lisinopril-d5 EP impurity G), which is is an angiotensin-converting enzyme (ACE) inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.

References : Nemoto S. et al.: J. Am Coll Cardiol, 40(1), 149-154, 2002; Swaan P. W. et al.: Biochim Biophys Acta,1236(1), 31-38, 1995; Mantle D. et al.: Clin Chim Acta, 299(1-2), 1-10, 2000; Mohammadi-Karakani A. et al.: Clin Chim Acta, 367(1-2), 170-174, 2006; Duman S. et al.: Int. J. Artif Organs,28(2), 156-163, 2005; Selim Isbir C.et al.: Cell Biochem Funct, 18(2), 85-91, 2000.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.