[219677-82-4]    

Synonyms : (2S)-2-((3S)-3-(4-Aminobutyl)-1,4-dioxohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-4-phenylbutanoic acid; R,S,S-Diketopiperazine

Applications : This is an impurity of Lisinopril (Lisinopril EP impurity D), which is is an angiotensin-converting enzyme (ACE) inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.

References : Nemoto S. et al.: J. Am Coll Cardiol, 40(1), 149-154, 2002; Swaan P. W. et al.: Biochim Biophys Acta,1236(1), 31-38, 1995; Mantle D. et al.: Clin Chim Acta, 299(1-2), 1-10, 2000; Mohammadi-Karakani A. et al.: Clin Chim Acta, 367(1-2), 170-174, 2006; Duman S. et al.: Int. J. Artif Organs,28(2), 156-163, 2005; Selim Isbir C.et al.: Cell Biochem Funct, 18(2), 85-91, 2000.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.