[15362-40-0]    

MFCD00451393

Synonyms : 1-(2,6-Dichlorophenyl)indolin-2-one; Diclofenac amide

Applications : This is an impurity of Diclofenac (Diclofenac EP impurity A), which is a nonsteroidal anti-inflammatory drug that has analgesic, anti-inflammatory, and antipyretic properties, and has been shown to be effective in treating a variety of acute and chronic pain and inflammatory conditions. It inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency.

References : Cho M. et al.: FEBS Lett, 579(20), 4213-4218, 2005; Lee H. M. et al.: Brain Res, 992(1), 120-127, 2003; Triebskorn R. et al.: Aquat Toxicol, 68(2), 151-166, 2004; Petrescu I. et al.: Biochim Biophys Acta, 1318(3), 385-394, 1997.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.