Synonyms : 1-(Bis(4-cyanophenyl)methyl)-1H-1,2,4-triazole 2-oxide

Applications : Letrozole N-oxide is an impurity of Letrozole, which is a third generation inhibitor of aromatase, used in the treatment of hormonally-responsive breast cancer after surgery.

References : Haynes B. P. et al.: J. Steroid Biochem Mol Biol., 87(1), 35-45, 2003; Bhatnagar A. S. et al.: J. Steroid Biochem Mol Biol., 37(6), 1021-1027, 1990; Mitropoulou T. N. et al. Int. J. Cancer., 104(2), 155-160, 2003; Dellapasqua S. et al.: Expert Opin Drug Metab Toxicol., 6(2), 251-259, 2010; Lee K. et al.: Int J Cancer., 62(3), 297-302, 1995; Steele R. E. et al.: Steroids, 50(1-3), 147-161, 1987.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.