[112809-51-5]    

MFCD00866241

Synonyms : 4,4'-((1H-1,2,4-Triazol-1-yl)methylene)dibenzonitrile; CGS-20267

Applications : Letrozole is a third generation inhibitor of aromatase with IC50 of 0.07-20 nM in cell-free assays. It has no effect on the plasma levels of 17α-OH progesterone, thyroid-stimulating hormone (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), or androstenedione and does not affect normal urine electrolyte excretion or thyroid function in clinical studies.

References : Haynes B. P. et al.: J. Steroid Biochem Mol Biol., 87(1), 35-45, 2003; Bhatnagar A. S. et al.: J. Steroid Biochem Mol Biol., 37(6), 1021-1027, 1990; Mitropoulou T. N. et al. Int. J. Cancer., 104(2), 155-160, 2003; Dellapasqua S. et al.: Expert Opin Drug Metab Toxicol., 6(2), 251-259, 2010; Lee K. et al.: Int J Cancer., 62(3), 297-302, 1995; Steele R. E. et al.: Steroids, 50(1-3), 147-161, 1987.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.