Synonyms : 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-5-methyl-4-(piperidin-4-yl)phenyl)pyrimidine-2,4-diamine hydrochloride

Applications : This is an impurity of of Ceritinib. A second-generation, orally active, selective inhibitor of anaplastic lymphoma kinase (ALK). Ceritinib blocks autophosphorylation of ALK, which inhibits downstream signaling proteins and prevents proliferation of ALK- dependent cancer cells, used for the treatment of non-small cell lung cancer.

References : Flick C. A et al.: Bioorg. Med. Chem. 24(9), 1937-1980, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.