[287118-97-2]    

MFCD08062164

Synonyms : 2-(Acetyloxy)benzoic acid 4-(nitroxymethyl)phenyl ester; NCX 4040

Applications : NO-Aspirin is a nitric oxide-donating form of aspirin. NCX 4040 inhibits cyclooxygenase activity and releases NO, which can down-regulate COX2 expression and reduce the levels of superoxide accumulation. In the human monocytic cell line THP1, the compound inhibits PGE2 production and cytokine expression, and appears to stabilize IkB by inhibiting proteasome function. NCX 4040 has been shown to induce apoptosis in several tumour cell lines.

References : Tesei A. et al.: Journal of Translational Medicine, 3(1), 7, 2005; Anna Tesei A et al.: Journal of Translational Medicine, 5, 52, 2007; Marvasi et al.: AMB Express, 6(1), 49, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.