[175033-36-0]    

MFCD01939436

Synonyms : 2-(Acetyloxy)benzoic acid 3-(nitroxymethyl)phenyl ester; NCX 4016

Applications : NO-Aspirin 1 is a hybrid molecule of aspirin and a nitric oxide (NO) donor. It contains an ester linkage, that when cleaved by esterases in the gut, liver, and plasma releases salicylate and an NO-releasing moiety. It also prevents restinosiis, inhibits proliferation of vascular smooth muscle cells, reduces infarct ssize following cardiac ischemia, and exhibits strong chemopreventative effects against colon cancer development.

References : Wallace J.L. et al.: Nature Reviews Drug Discovery, 1, 375, 2002; Chiroli V. et al.: Eur. J. Med. Chem., 38, 441, 2003.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.