[147084-10-4]    

MFCD09954106

Synonyms : 11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepine-3-carbaldehyde; Lastacaft; R89674

Applications : Alcaftadine is a high affinity ligand for the H1 receptor, with a pKi (8.5) that is comparable with that of other H1 antihistamines. Alcaftadine is also an antagonist for H2 and H4 receptors with no affinity for the H3 receptor. It is used to prevent eye irritation and treat the signs and symptoms of allergic conjunctivitis.

References : Ding H. X. et al.: Bioorg. Med. Chem. 21(11), 2795-2825, 2013.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.