[133407-82-6]    

MFCD00674886

Synonyms : Benzyl ((S)-4-methyl-1-(((S)-4-methyl-1-(((S)-4-methyl-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)carbamate; Z-Leu-Leu-Leu-al; MG13

Applications : MG-132 is a potent proteasome and calpain inhibitor with IC50s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis.

References : Harhouri K. et al.: EMBO Mol Med., 9(9), 1294-1313., 2017; Fan W. H. et al.: Acta Pharmacol Sin., 32(5), 619-25, 2011; Tsubuki S. et al.: J. Biochem., 119(3), 572-6, 1996; Fiedler M. A. et al.: Am. J. Respir Cell Mol Biol., 19(2), 259-68, 1998; MacLaren A. P. et al.: Cell Death Differ., 8(3), 210-8, 2001; Han Y. H. et al.: Oncol Rep., 22(1), 215-21, 2009; Dang L. et al.: Int J Mol Med., 33(5), 1083-8, 2014; Matsumoto Y. et al.: Cancer Sci. 107(6), 773-81, 2016; Bonuccelli G. et al.: Am J Pathol., 163(4), 1663-75, 2003.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.