[960374-59-8]    

MFCD26794217

Synonyms : (S)-3-(4-Methoxyphenyl)-N-((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)propanamido)propanamide; ONX-0914

Applications : PR-957 is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. PR-957 blocks cytokine production and attenuates progression of experimental arthritis. PR-957 is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (Ki=5.2 μM). PR-957 reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1.

References : Muchamuel T. et al.: Nat Med., 15(7), 781-787, 2009; Rozman K. et al.: Molecules 25(6), 1305, 2020; Lin J. et al.: Biochem Pharmacol., 156, 511-523, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.