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SL-3757

4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoic acid, 98%

CAS No. : 
[137281-39-1]    

Price and Availability
Pack Size Price in USD Quantity Availability Shipping Status
100MG100.00 Back Order Estimated to Ship on 12.06.2024
500MG400.00 Back Order Estimated to Ship on 12.06.2024
Chemical Properties
C15H14N4O3 298.30
Solid Not available
For Laboratory research use only, not for drug, household or other uses.
Applications : It is an advanced key intermediate in the preparation of Pemetrexed and related analogs, which is a novel antifolate and antimetabolite for dihydrofolate reductase-thymidylate synthase (DHFR-TS). It is used to treat for pleural mesothelioma (cancer of the outer covering of the lungs) non small cell lung cancer (NSCLC).
References : Shih C. et al.: Cancer Res., 57(6), 1116-1123, 1997; Iwahori K. et al.: Int J. Cancer., 132(2), 459-471, 2013; Teicher B. A. et al.: Clin. Cancer Res. , 6(3), 1016-1023, 2000.
Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.
Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Product ID : SL-3757

Product Name : 4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoic acid

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