SynInnova Laboratories Inc.

SL-2585

Desmethyl bosentan, 98% (HPLC)

CAS No. :

[253688-61-8]

MDL No. :

MFCD09840361

Synonyms : 4-(tert-Butyl)-N-(6-(2-hydroxyethoxy)-5-(2-hydroxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide; Bosentan O-desmethyl impurity; Ro 47-8634

Price and Availability
Pack Size	Price in USD	Quantity	Availability	Shipping Status
5MG	680.00	- +	Back Order	Estimated to Ship on 12.21.2024
10MG	1280.00	- +	Back Order	Estimated to Ship on 12.21.2024

Chemical Properties
Mol. Formula : C₂₆H₂₇N₅O₆S	Mol. Weight : 537.59
Appearance : Yellow solid	Melting Point : Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Desmethyl bosentan is a metabolite of Bosentan, which is a competitive and dual antagonist of endothelin-1 (ET) for the ET_Aand ET_B receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively.

References : Dhillon S. et al.: Am J. Cardiovasc Drugs 9 (5), 331-350, 2009; Akamata K. et al. Arthritis Res Ther. 16 (2), R86, 2014; Iglarz M. et al. Life Sci. 118 (2), 333-339, 2014; Son G. Y. et al. PLoS One 11(12), e0167713, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Product ID : SL-2585

Product Name : Desmethyl bosentan

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SL-2585

Desmethyl bosentan, 98% (HPLC)

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