SynInnova Laboratories Inc.

SL-2592

Hydroxy desmethyl bosentan-d₄, 98% (HPLC)

Isotopic Purity :

98 atom % D

Synonyms : 4-(1-Hydroxy-2-methylpropan-2-yl)-N-(6-(2-hydroxyethoxy-d₄)-5-(2-hydroxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide; Bosentan hydroxymethyl O-desmethyl-d₄ impurity

Price and Availability
Pack Size	Price in USD	Quantity	Availability	Shipping Status
5MG	980.00	- +	Back Order	Estimated to Ship on 12.21.2024
10MG	1880.00	- +	Back Order	Estimated to Ship on 12.21.2024

Chemical Properties
Mol. Formula : C₂₆H₂₃D₄N₅O₇S	Mol. Weight : 557.61
Appearance : Pale yellow solid	Melting Point : Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Hydroxy desmethyl bosentan-d4 is a deuterium labelled metabolite of Bosentan, which is a competitive and dual antagonist of endothelin-1 (ET) for the ET_Aand ET_B receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively.

References : Dhillon S. et al.: Am J. Cardiovasc Drugs 9 (5), 331-350, 2009; Akamata K. et al. Arthritis Res Ther. 16 (2), R86, 2014; Iglarz M. et al. Life Sci. 118 (2), 333-339, 2014; Son G. Y. et al. PLoS One 11(12), e0167713, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Product ID : SL-2592

Product Name : Hydroxy desmethyl bosentan-d₄

Note : If you do not find your required compound in our catalogue, or not commercially available, please contact us, we will assist you to get your desired molecule. We only charge if we deliver to your satisfaction.

Site is under construction and it will coming soon. Please contact us at sales@syninnova.com for COA. Thank you!

Site is under construction and it will coming soon. Please contact us at sales@syninnova.com for HNMR. Thank you!

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SL-2592

Hydroxy desmethyl bosentan-d4, 98% (HPLC)

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