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SL-2590

Hydroxy bosentan-d6, 98% (HPLC)

Isotopic Purity : 
98 atom % D
CAS No. : 
[1246817-57-1]    
MDL No. : 
MFCD19705154
Synonyms : 4-(1-Hydroxy-2-methylpropan-2-yl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide-d6

Price and Availability
Pack Size Price in USD Quantity Availability Shipping Status
5MG880.00
-
+
Back Order Estimated to Ship on 12.21.2024
10MG1680.00
-
+
Back Order Estimated to Ship on 12.21.2024
Chemical Properties
C27H23D6N5O7S 573.65
Off-white solid Not available
For Laboratory research use only, not for drug, household or other uses.
Applications : Hydroxy bosentan-d6 is a deuterium labelled active metabolite of Bosentan, which is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively.
References : Dhillon S. et al.: Am J. Cardiovasc Drugs 9 (5), 331-350, 2009; Akamata K. et al. Arthritis Res Ther. 16 (2), R86, 2014; Iglarz M. et al. Life Sci. 118 (2), 333-339, 2014; Son G. Y. et al. PLoS One 11(12), e0167713, 2016.
Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.
Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Product ID : SL-2590

Product Name : Hydroxy bosentan-d6

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