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SL-4997

Ambrisentan ethyl ester, >98%

CAS No. : 
[1349854-31-4]    
Synonyms : Ethyl (S)-2-((4,6-dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoate

Price and Availability
Pack Size Price in USD Quantity Availability Shipping Status
100MG180.00
-
+
Back Order Estimated to Ship on 01.20.2025
250MG400.00
-
+
Back Order Estimated to Ship on 01.20.2025
500MG750.00
-
+
Back Order Estimated to Ship on 01.20.2025
Chemical Properties
C24H26N2O4 406.48
Solid Not available
For Laboratory research use only, not for drug, household or other uses.
Applications : This is an advanced key intermediate in the preparation of Ambrisentan, which is a highly selective antagonist of the endothelin-1 type A receptor (ETAR), used in the treatment of pulmonary arterial hypertension (PAH).
References : Weiss J. et al.: Eur J Pharmacol, 660(2-3), 298-304, 2011; Yokoyama Y. et al.: Biol Pharm Bull, 37(3), 461-465, 2014; Weiss J. et al.: Biochem Pharmacol, 85(2), 265-273, 2013; Osano A. et al.: J. Pharmacol Sci, 124(1), 86-91, 2014; Buckley M. S. et al.: Expert Opin Drug Metab Toxicol, 7(3), 371-380, 2011.
Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.
Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Product ID : SL-4997

Product Name : Ambrisentan ethyl ester

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