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SL-4997

Ambrisentan ethyl ester, >98%

CAS No. : 
[1349854-31-4]    
Synonyms : Ethyl (S)-2-((4,6-dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoate

Price and Availability
Pack Size Price in USD Quantity Availability Shipping Status
100MG180.00 Back Order Estimated to Ship on 12.15.2024
250MG400.00 Back Order Estimated to Ship on 12.15.2024
500MG750.00 Back Order Estimated to Ship on 12.15.2024
Chemical Properties
C24H26N2O4 406.48
Solid Not available
For Laboratory research use only, not for drug, household or other uses.
Applications : This is an advanced key intermediate in the preparation of Ambrisentan, which is a highly selective antagonist of the endothelin-1 type A receptor (ETAR), used in the treatment of pulmonary arterial hypertension (PAH).
References : Weiss J. et al.: Eur J Pharmacol, 660(2-3), 298-304, 2011; Yokoyama Y. et al.: Biol Pharm Bull, 37(3), 461-465, 2014; Weiss J. et al.: Biochem Pharmacol, 85(2), 265-273, 2013; Osano A. et al.: J. Pharmacol Sci, 124(1), 86-91, 2014; Buckley M. S. et al.: Expert Opin Drug Metab Toxicol, 7(3), 371-380, 2011.
Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.
Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Product ID : SL-4997

Product Name : Ambrisentan ethyl ester

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